Phenotype Image Detail

Image

Caption

B-D: Hart's staining of the transverse sections of ligated arteries. Neointima and vascular remodleing were compared between wild-type (B), Fbln5^tm1Eno/Fbln5^tm1Eno carotid arteries (C) and Eln^tm1Dyl/Eln⁺ carotid arteries after 28 days of ligation. Both Fbln5^tm1Eno/Fbln5^tm1Eno carotid arteries and Eln^tm1Dyl/Eln⁺ carotid arteries exhibited decreased extensibility; however, there was no outward remodeling or increased neointima formation in the Eln^tm1Dyl/Eln⁺ vessel. Scalebar: 40um

Copyright

This image is from Spencer JA, Proc Natl Acad Sci U S A 2005 Feb 22;102(8):2946-51. Copyright 2005 National Academy of Sciences, U.S.A. J:96831

Associated Alleles

Symbol	Name
Eln^tm1Dyl	elastin; targeted mutation 1, Dean Y Li
Fbln5^tm1Eno	fibulin 5; targeted mutation 1, Eric N Olson

Associated Genotypes

Allelic Composition	Genetic Background
Fbln5^tm1Eno/Fbln5^tm1Eno	involves: 129S6/SvEvTac * C57BL/6
Eln^tm1Dyl/Eln^+	involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6