Phenotype Image Detail

Image

Caption

A: Section of a polypoid growth in the distal colon exhibiting a spherical elevation with stalk presenting on the flat mucosa. B: Multiple tumors located in the first segment of the duodenum of an Apc^tm1Rak/Apc⁺ mouse. C: Section of an adenocarcinoma of the small intestine with infiltration of the carcinoma into the inner layer of the muscularis (arrow). D: Section of liver showing a metastatic adenocarcinoma from a 12 month old Apc^tm1Rak/Apc⁺ mouse. Magnification: A & C: x60; D: x580

Copyright

This image is from Fodde R, Proc Natl Acad Sci U S A 1994 Sep 13;91(19):8969-73. Copyright 1994 National Academy of Sciences, U.S.A. J:20443

Associated Alleles

Symbol	Name
Apc^tm1Rak	APC, WNT signaling pathway regulator; targeted mutation 1, Raju Kucherlapati

Associated Genotypes

Allelic Composition	Genetic Background
Apc^tm1Rak/Apc^+	involves: 129P2/OlaHsd * C57BL/6