Phenotype Image Detail

Image

Caption

Wild-type (A,C,E,G,I & K), and Nkx3-2^tm1Bobh/Nkx3-2^tm1Bobh (B,D,F,H,J & L) E18.5 mice. In a dorsal view, the homozygous mutant fetus (B) has a slightly shortened skeleton, more highly compact vertebrae, and lateral extension of the ribs as compared with wild type (A). C and D are viewed ventrally, which shows that the ribs and sternum are unaffected in the mutant (D). Wild-type (E and G) and mutant (F and H) cervical vertebrae are shown dorsally (E and F) and ventrally (G and H). In E and F, the cervical vertebrae are highlighted by the bracket showing the compression of the mutant vertebrae (F). In G and H, the midline is indicated by the upper white arrowhead showing the medial ossification centers (red button of stain). The midline clefting seen in the mutant thoracic vertebrae is shown by the lower white arrowhead. A lateral view of the lumbar (I and J) region shows that the elements that form the neural arches are more narrow in the mutant (J). The arrowhead points to the last lumbar vertebra for comparison. The fetal tails are shown in K and L. The mutant tail (L) is shorter and thicker, and the vertebrae are missing the anterior processes (arrowhead).

Copyright

This image is from Lettice LA, Proc Natl Acad Sci U S A 1999 Aug 17;96(17):9695-700. Copyright 1999 National Academy of Sciences, U.S.A. J:57112

Associated Alleles

Symbol	Name
Nkx3-2^tm1Bobh	NK3 homeobox 2; targeted mutation 1, Robert E Hill

Associated Genotypes

Allelic Composition	Genetic Background
Nkx3-2^tm1Bobh/Nkx3-2^tm1Bobh	involves: 129P2/OlaHsd * C57BL/6