Phenotype Image Detail

Image

Caption

Transverse sections are shown for E18.5 (A-D) and E14.5 (E-J) wild-type (A,C,E,G & I) and Nkx3-2^tm1Bobh/Nkx3-2^tm1Bobh (B,D,F,H & J) embryos. A,B,E and F are sections at the level of the cervical vertebrae, C,D,G,and H, the thoracic vertebrae, and I and J, the lumbar vertebrae. At E18.5 the notochord has given rise to the nucleus pulposum (arrowhead in A and C) surrounded by the vertebral body. In the mutant (B and D), these elements are missing, and the arrowheads indicate the vestigial notochord. Note the ventral bridges of the neural arches (arrow in D). At E14.5, cells in the wild type have organized at the ventral midline around the notochord (black arrowhead) at all axial levels (E, G, and I). In the mutant, few cells organize around the notochord in the cervical and thoracic vertebrae (F and H). In the lumbar region (J), more cells are apparent (arrow), but are not well organized. SC, spinal cord; NA, neural arch; L, lung; Ad, Adrenal; and K, Kidney.

Copyright

This image is from Lettice LA, Proc Natl Acad Sci U S A 1999 Aug 17;96(17):9695-700. Copyright 1999 National Academy of Sciences, U.S.A. J:57112

Associated Alleles

Symbol	Name
Nkx3-2^tm1Bobh	NK3 homeobox 2; targeted mutation 1, Robert E Hill

Associated Genotypes

Allelic Composition	Genetic Background
Nkx3-2^tm1Bobh/Nkx3-2^tm1Bobh	involves: 129P2/OlaHsd * C57BL/6