Phenotype Image Detail

Image

Caption

Ventral views of the skull of wild-type (A) and Nkx3-2^tm1Bobh/Nkx3-2^tm1Bobh (B) at E18.5 show a decrease in size of the basioccipital bone and posterior basisphenoid bone. C-F: Sagittal sections of wild-type (C & E) and mutant (D & F) embryos at E14.5 near the midline of the axial skeleton through the notochord region. C and D are sections from the cervical region. The characteristic notochordal swellings are shown in C (open arrowhead indicates characteristic swelling). The thin mutant notochord is indicated by the open arrowhead in D. The condensing cells of the anterior located basioccipital bone (in C, designated BO) are missing in the mutant (region indicted by filled arrowhead in D). More posteriorly, the periodic notochordal swellings in wild type (open arrowhead in E) are abnormal in the mutant (F). Abbreviations: anterior arch of the atlas (AT); spinal cord (BO); basioccipital (BO); posterior basisphenoid (BS)

Copyright

This image is from Lettice LA, Proc Natl Acad Sci U S A 1999 Aug 17;96(17):9695-700. Copyright 1999 National Academy of Sciences, U.S.A. J:57112

Associated Alleles

Symbol	Name
Nkx3-2^tm1Bobh	NK3 homeobox 2; targeted mutation 1, Robert E Hill

Associated Genotypes

Allelic Composition	Genetic Background
Nkx3-2^tm1Bobh/Nkx3-2^tm1Bobh	involves: 129P2/OlaHsd * C57BL/6