Phenotype Image Detail

Image

Caption

Severe abnormalities in the Cbp heterozygote of a BALB/c * C57BL/6-CBA background. Bone and cartilage stained specimens of the right forelimbs of a wild type (A) and a Crebbp^tm1Sis/Crebbp⁺ (B) exhibiting postaxial oligodactyly (*). The sternums and ribs of the wild type (C) and the heterozygous mutant mouse (D). Note six right ribs and misalignment of the rib pairs on the sternum (*) in the heterozygous mouse. Dorsal view of the vertebrae of a wild type (E) and mutant mouse (F). In the heterozygous mutant mouse, the presence of 10 ribs on the right side, 14 ribs on the left side, asymmetric cervical vertebrae, extra and split thoracic vertebrae, and scoliosis were observed. Higher magnification (x2) of E (G) and F (H). Asymmetric cervical vertebrae indicated by a bracket were observed in the heterozygous mutant mouse.

Copyright

This image is from Tanaka Y, Proc Natl Acad Sci U S A 1997 Sep 16;94(19):10215-20. Copyright 1997 National Academy of Sciences, U.S.A. J:42932

Associated Alleles

Symbol	Name
Crebbp^tm1Sis	CREB binding protein; targeted mutation 1, Shunsuke Ishii

Associated Genotypes

Allelic Composition	Genetic Background
Crebbp^tm1Sis/Crebbp^+	involves: C57BL/6NCrlj * CBA/JNCrlj