Phenotype Image Detail

Image

Caption

A: Bony outgrowth or osteophyte formation. Mason's trichrome staining for collagen (blue) or safranin O staining for proteoglycans (red) was performed on knee joint sections prepared from a 3-month-old Errfi1^tm1Gvw/Errfi1^tm1Gvw mouse. Arrows indicate the abnormal outgrowing nodules that have abundant collagen and proteoglycan. Von Kossa staining of calcium deposition was performed on undecalcified knee joint sections prepared from a 5.5-month-old homozygous mutant mouse. Arrowheads indicate matrical calcium in the inner zone of the nodules. B: Degradation of articular cartilage. Arrows indicate rough joint surface and degraded articular cartilage in a 4-month-old mutant mouse knee joint stained with safranin O. C: Subchondral cyst formation. Two large cysts filled with or lacking fibroblast-like cells are observed beneath degraded articular cartilage in a 3-month-old mutant mouse knee joint as indicated by the arrowheads. D: Synovial hyperplasia. H&E knee joint sections were prepared from 2-month-old age-matched heterozygous and homozygous mutant mice. Compared with a thin layer of synovial lining in a heterozygous joint (normal), multilayers of synovial lining cells (Sy) are observed in a mutant mouse joint. E: Vascularization in the normally avascular joint region. Various size of blood vessels indicated by arrows are observed in a 4-month-old mutant knee joint, accompanied by newly repaired tissues.

Copyright

This image is from Zhang YW, Proc Natl Acad Sci U S A 2005 Aug 16;102(33):11740-5. Copyright 2005 National Academy of Sciences, U.S.A. J:100927

Associated Alleles

Symbol	Name
Errfi1^tm1Gvw	ERBB receptor feedback inhibitor 1; targeted mutation 1, George F Vande Woude

Associated Genotypes

Allelic Composition	Genetic Background
Errfi1^tm1Gvw/Errfi1^tm1Gvw	Not Specified