Phenotype Image Detail

Image

Caption

Knee joint sections were prepared from a 3-month-old homozygous mutant mouse and immunohistochemically stained by anti-PCNA or anti-collagen type II antibodies. The spindle-shaped mesenchymal-like cells at the edge of the bony nodule display PCNA-positive staining (brown); no PCNA-positive cells were observed in the inner zone of the bony nodule. In contrast with the PCNA staining pattern, only a narrow zone of chondrocytes between the PCNA-positive cells and the well differentiated chondrocytes in the deeper zone display collagen type II staining (brown). PCNA-positive cells are also observed in areas where articular cartilage has been degraded and replaced by newly formed tissues (arrows). The lower photos are higher magnification images taken from the fields indicated in upper photos. nod, nodule; ar, articular cartilage.

Copyright

This image is from Zhang YW, Proc Natl Acad Sci U S A 2005 Aug 16;102(33):11740-5. Copyright 2005 National Academy of Sciences, U.S.A. J:100927

Associated Alleles

Symbol	Name
Errfi1^tm1Gvw	ERBB receptor feedback inhibitor 1; targeted mutation 1, George F Vande Woude

Associated Genotypes

Allelic Composition	Genetic Background
Errfi1^tm1Gvw/Errfi1^tm1Gvw	Not Specified