Phenotype Image Detail

Image

Caption

Histological analysis of tibial sections from 21 day old (A) and 115 day old (B) wild-type (left), Slc34a1^tm1Hten/Slc34a1⁺ (center) and Slc34a1^tm1Hten/Slc34a1^tm1Hten (right) mice reveals that at 21 days old the homozygous mice have poorly developed metaphyseal trabeculae and retarded secondary ossification in the epiphysis when compared with wild-type littermates. In the heterozygous mice these features are intermediate between wild type and homozygous littermates. At 155 days of age, the number of metaphyseal trabeculae in the homozygous mice is significantly greater than that of the wild type littermates and the area of epiphyseal bone marrow is partially occupied with calcified bone.

Copyright

This image is from Beck L, Proc Natl Acad Sci U S A 1998 Apr 28;95(9):5372-7. Copyright 1998 National Academy of Sciences, U.S.A. J:47637

Associated Alleles

Symbol	Name
Slc34a1^tm1Hten	solute carrier family 34 (sodium phosphate), member 1; targeted mutation 1, Harriet S Tenenhouse

Associated Genotypes

Allelic Composition	Genetic Background
Slc34a1^tm1Hten/Slc34a1^tm1Hten	involves: 129S2/SvPas * C57BL/6J