Phenotype Image Detail

Image

Caption

A: Cross sections through basal turns of cochleae from control and Lhfpl5^hscy/Lhfpl5^hscy mice at 4 months of age. The homozygous mutant cochleae exhibit severe degeneration of the organ of Corti and secondary degeneration of spiral ganglion cells. B: SEM examinations of OC surface preparations from cochleae of control and mutant mice at postnatal ages P0 and P8, and from mutant mice at P15 and P50. In P8 mutants, hair bundle disorganization and some hair cell loss is apparent; by P50, few stereocilia remain, and most outer hair cells have degenerated in basal portions of the cochlea. Abbreviations: organ of Corti (OC); spiral ganglion cells (SG)

Copyright

This image is from Longo-Guess CM, Proc Natl Acad Sci U S A 2005 May 31;102(22):7894-9. Copyright 2005 National Academy of Sciences, U.S.A. J:98396

Associated Alleles

Symbol	Name
Lhfpl5^hscy	lipoma HMGIC fusion partner-like 5; hurry-scurry

Associated Genotypes

Allelic Composition	Genetic Background
Lhfpl5^hscy/Lhfpl5^hscy	B6(MOR)-Lhfpl5^hscy/J