Phenotype Image Detail

Image

Caption

Hematoxylin/eosin staining of age-matched wild-type (A, C & E) and Bbs2^tm1Vcs/Bbs2^tm1Vcs (B, D & F) mouse retinas. Mice were examined at 7 week ( A & B), 5 months ( C & D), and 10 months ( E & F). Some degenerative changes in the ONL are apparent in the 7 weeks old mice, although inner and outer segments are clearly distinguishable. By 5 months of age (C & D), the distinction between inner and outer segments is less apparent and the ONL is significantly thinner than in wild-type eyes. At 10 months of age (E & F), the ONL is largely degenerated and no inner or outer segments are present. Abbreviations: retinal pigment epithelium (RPE); inner segments (IS); outer segments (OS); inner nuclear layer (INL); outer nuclear layer (ONL); ganglion cell layer (GCL). Magnification: x160

Copyright

This image is from Nishimura DY, Proc Natl Acad Sci U S A 2004 Nov 23;101(47):16588-93. Copyright 2004 National Academy of Sciences, U.S.A. J:94467

Associated Alleles

Symbol	Name
Bbs2^tm1Vcs	Bardet-Biedl syndrome 2; targeted mutation 1, Val C Sheffield

Associated Genotypes

Allelic Composition	Genetic Background
Bbs2^tm1Vcs/Bbs2^tm1Vcs	either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)