Phenotype Image Detail

Image

Caption

A: Alizarin red (bone) and Alcian blue (cartilage) staining of Lmnb1^Gt(XA130)Byg/Lmnb1^Gt(XA130)Byg skeleton (left) shows a flattened skull, an abnormal vertebral column, and reduced ossification in phalanges, talus and calcaneus (arrows). B: Dorsal view of cranial vault. Alizarin red stain shows closure of the coronal sutures between pariental and frontal bones (arrows) and overlapping of the parietal (p) bones at the sagittal suture (arrowhead) in the homozygous mutant embryo (left). C: Removal of scalp reveals obscured view of underlying blood vessels due to suture closure in the homozygous mutant embryo (left).

Copyright

This image is from Vergnes L, Proc Natl Acad Sci U S A 2004 Jul 13;101(28):10428-33. Copyright 2004 National Academy of Sciences, U.S.A. J:91473

Associated Alleles

Symbol	Name
Lmnb1^Gt(XA130)Byg	lamin B1; gene trap XA130, BayGenomics

Associated Genotypes

Allelic Composition	Genetic Background
Lmnb1^Gt(XA130)Byg/Lmnb1^Gt(XA130)Byg	involves: 129P2/OlaHsd * C57BL/6J