Phenotype Image Detail

Image

Caption

A comparative study of Egfr^wa2/Egfr^wa2 (A, C, & E) and Egfr^wa2/Egfr^wa2 Ptpn11^tm1Paw/⁺ (B,D & F) newborn mice. A & B: Section of abdomenal skins. In severely affected Egfr^wa2/Egfr^wa2 Ptpn11^tm1Paw/⁺ mouse, skin was poorly developed with no or few disorganized hair follicles, thinner epidermis, reduced subcutaneous fat or muscle tissue mass. Hematoxylin/eosin stained. C & D: Lung sections. There was a marked reduction in the size of aveolar spaces (atelectasis) and an increase in the thickness of aveolar walls in the Egfr^wa2/Egfr^wa2 Ptpn11^tm1Paw/⁺ mice. Hematoxylin/eosin stained. E & F: Small bowel. The lumen is filled with desquamated cells, giving a solid appearance. Hematoxylin/ eosin stained. Magnifications: A,B,E & F: x280; C & D: x200

Copyright

This image is from Qu CK, Proc Natl Acad Sci U S A 1999 Jul 20;96(15):8528-33. Copyright 1999 National Academy of Sciences, U.S.A. J:75413

Associated Alleles

Symbol	Name
Egfr^wa2	epidermal growth factor receptor; waved 2
Ptpn11^tm1Paw	protein tyrosine phosphatase, non-receptor type 11; targeted mutation 1, Anthony Pawson

Associated Genotypes

Allelic Composition	Genetic Background
Egfr^wa2/Egfr^wa2 Ptpn11^tm1Paw/Ptpn11^+	involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn a/A-Egfr^wa2 Wnt3a^vt * C57BL/6