Phenotype Image Detail

Image

Caption

A-F: Hematoxylin/eosin staining of sagittal sections of wild-type embryos (A, C, and E) and Rad50^tm1Jpt/Rad50^tm1Jpt embryos ( B, D, & F) at E6.0 ( A & B), E6.5 ( C & D) and E7.5 (E & F). Note the smaller size of the mutant embryos. By E6.5, the homozygous mutant embryo has not developed appreciably beyond E6.0 stage. In many cases, the mutant embryo is in the process of being resorbed. By E7.5, the homozygous mutant embryo is completely resorbed. G-J: BrdUrd labeling of proliferating cells in wild-type ( G & I) and mutant ( H & J) embryos at E6.0 and E6.5 respectively. Scalebar A-F: 100um

Copyright

This image is from Luo G, Proc Natl Acad Sci U S A 1999 Jun 22;96(13):7376-81. Copyright 1999 National Academy of Sciences, U.S.A. J:56083

Associated Alleles

Symbol	Name
Rad50^tm1Jpt	RAD50 double strand break repair protein; targeted mutation 1, John H J Petrini

Associated Genotypes

Allelic Composition	Genetic Background
Rad50^tm1Jpt/Rad50^tm1Jpt	involves: 129S7/SvEvBrd