Phenotype Image Detail

Image

Caption

Lung tissue from wild type (A) and Sftpd^tm1Jhf/Sftpd^tm1Jhf mice (B-D) at 7 months of age. Moderate (B) to severe (C) emphysematous changes were observed in the homozygous mutant mice compared with age-matched wild type mice. Focal areas of macrophage accumulation and perivascular/peribronchiolar monocytic infiltrates also were observed in the lungs of 7-month-old mutant mice (D). Scale bar 100um

Copyright

This image is from Wert SE, Proc Natl Acad Sci U S A 2000 May 23;97(11):5972-7. Copyright 2000 National Academy of Sciences, U.S.A. J:62282

Associated Alleles

Symbol	Name
Sftpd^tm1Jhf	surfactant associated protein D; targeted mutation 1, James H Fisher

Associated Genotypes

Allelic Composition	Genetic Background
Sftpd^tm1Jhf/Sftpd^tm1Jhf	involves: 129P2/OlaHsd * Black Swiss