Phenotype Image Detail

Image

Caption

A: A cross section of the descending thoracic aorta from a wild type mouse showing uninterrupted elastic laminae. Toluidine blue staining, light microscopy, x400. B: A cross section of the descending thoracic aorta from a Gulo^tm1Mae/Gulo^tm1Mae mouse with disrupted laminae. Light microscopy, x400. C: TEM of the area adjacent to that shown in B. A single layer of mildly activated smooth muscle cells (smc) is present in the intima between endothelial cells (ec) and superficial elastic lamina (sel). A break in the elastica is marked by an arrow. Magnification: x4,000. D: Scanning electron microscopy of the aortic arch of a wild type mouse showing a normal luminal surface. lca, left carotid artery; rca, right carotid artery. Magnification: x20. E: Scanning electron microscopy of the aortic arch of a mutant mouse showing multiple longitudinal surface defects (arrows). Magnification x20. F: Higher magnification (x200) of the defect.

Copyright

This image is from Maeda N, Proc Natl Acad Sci U S A 2000 Jan 18;97(2):841-6. Copyright 2000 National Academy of Sciences, U.S.A. J:59931

Associated Alleles

Symbol	Name
Gulo^tm1Mae	gulonolactone (L-) oxidase; targeted mutation 1, Nobuyo Maeda

Associated Genotypes

Allelic Composition	Genetic Background
Gulo^tm1Mae/Gulo^tm1Mae	involves: 129 * C57BL/6