Phenotype Image Detail

Image

Caption

A & B: Hippocampal formation of wild type (A) and Psen2^tm1Bdes/Psen2^tm1Bdes (B) mice at 6 months of age showing no differences in architecture. C & D: Lung parenchyma of wild type (C) and mutant (D) mice at 3 months of age. Note the increase in cell mass and the reduction of alveolar space as compared with the wild type. E & F: Lung of a mutant mouse at 6 months of age exhibiting profuse hemorrhages. Both alveolar spaces and lower conductive airways are virtually filled with extravasated erythrocytes. F & G: Lung specimens of 6 month old mutant mice stained for single-stranded DNA after thermal denaturation (F) and tissue transglutaminase type II (G). Both markers for cells undergoing apoptosis label scattered cells within the lung parenchyma as well as in the corresponding blood vessels (BV) and bronchioli (BR). (H and I) Similar experiments carried out on wild type mice of the same age did not result in any staining either for tissue type transglutaminase (H) or single-stranded DNA (I).

Copyright

This image is from Herreman A, Proc Natl Acad Sci U S A 1999 Oct 12;96(21):11872-7. Copyright 1999 National Academy of Sciences, U.S.A. J:58118

Associated Alleles

Symbol	Name
Psen2^tm1Bdes	presenilin 2; targeted mutation 1, Bart de Strooper

Associated Genotypes

Allelic Composition	Genetic Background
Psen2^tm1Bdes/Psen2^tm1Bdes	involves: 129P2/OlaHsd * C57BL/6J