Phenotype Image Detail

Image

Caption

A: Craniofacial deformity in adult Lpar1^tm1Jch/Lpar1^tm1Jch mice. Note the blunted snout and more widely spaced eyes. B: Overall size decrease in homozygous mutant mice. Two 9-week-old male siblings are shown. C: Frontal cranial hemorrhage in a newborn mutant pup but not in littermates. D: Sagittal sections of an E13 mutant embryo with frontal cranial hemmorrhage (the earliest time point this phenotype was observed). Sections shown were stained to identify erythrocytes (left) using peroxidase (pseudocolored red) or Nissl substance (right) using cresyl violet.

Copyright

This image is from Contos JJ, Proc Natl Acad Sci U S A 2000 Nov 21;97(24):13384-9. Copyright 2000 National Academy of Sciences, U.S.A. J:65882

Associated Alleles

Symbol	Name
Lpar1^tm1Jch	lysophosphatidic acid receptor 1; targeted mutation 1, Jerod Chun

Associated Genotypes

Allelic Composition	Genetic Background
Lpar1^tm1Jch/Lpar1^tm1Jch	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J