Phenotype Image Detail

Image

Caption

A & B: The two upper panels display the yolk sac of Psen1^tm1Bdes/Psen1⁺ Psen2^tm1Bdes/Psen2^tm1Bdes (A) and Psen1^tm1Bdes/Psen1^tm1Bdes Psen2^tm1Bdes/Psen2^tm1Bdes (B) littermates (identical magnification). The arrowhead points to the vascular plexus. Although initial vascular plexus and primitive red blood cells form in the double mutant, organization into a discrete network of vitelline vessels is lacking, yolk sacs do not expand properly and often have a blistered appearance. C & D: Psen2^tm1Bdes/Psen2^tm1Bdes (C) and Psen1^tm1Bdes/Psen1⁺ Psen2^tm1Bdes/Psen2^tm1Bdes (D) embryos appear normal. E: The neural tube of E9.5 double homozygous embryos often has a kinked appearance. F: Psen1^tm1Bdes/Psen1^tm1Bdes embryos are only marginally retarded at E9.5. Magnification is identical for C-F

Copyright

This image is from Herreman A, Proc Natl Acad Sci U S A 1999 Oct 12;96(21):11872-7. Copyright 1999 National Academy of Sciences, U.S.A. J:58118

Associated Alleles

Symbol	Name
Psen1^tm1Bdes	presenilin 1; targeted mutation 1, Bart de Strooper
Psen2^tm1Bdes	presenilin 2; targeted mutation 1, Bart de Strooper

Associated Genotypes

Allelic Composition	Genetic Background
Psen1^tm1Bdes/Psen1^tm1Bdes Psen2^tm1Bdes/Psen2^tm1Bdes	involves: 129P2/OlaHsd * C57BL/6J