Phenotype Image Detail

Image

Caption

A-D: Hematoxylin and eosin stained liver and spleen sections from wild type and Tnf^tm1Ljo/Tnf^tm1Ljo mice 10 days after C. parvum treatment showing characteristic inflammatory responses in liver (A) and spleen (C) of wild type mice, and the absence of these responses and the preserved architecture of liver (B) and spleen (D) of the homozygous mutant mice. E-H: Liver and spleen sections from mice 40 days after C. parvum treatment showing the almost natural morphology typical of the down-regulated inflammatory response in liver parenchyma (E) and spleen (G) of wild type mice, and the late inflammatory infiltration in liver (F) and spleen (H) of the homozygous mutant mice.

Copyright

This image is from Marino MW, Proc Natl Acad Sci U S A 1997 Jul 22;94(15):8093-8. Copyright 1997 National Academy of Sciences, U.S.A. J:41992

Associated Alleles

Symbol	Name
Tnf^tm1Ljo	tumor necrosis factor; targeted mutation 1, Lloyd J Old

Associated Genotypes

Allelic Composition	Genetic Background
Tnf^tm1Ljo/Tnf^tm1Ljo	involves: 129S1/Sv