Phenotype Image Detail

Image

Caption

A-E: Selected serial transverse sections, from cephalad to caudad, of a Myh10^tm2Rsad/Myh10^tm2Rsad mouse heart. F: Transverse section of a wild type mouse heart at approximately the same level as C. G & H: Sagittal sections of another homozygous mutant mouse heart. I: Sagittal section of a wild type mouse heart. (Hematoxylin and eosin stained). (A) Cross-sectional view of the aorta and the pulmonary artery at the levels of the semilunar valves, showing the positions of the two vessels, and the uppermost portion of the lateral wall of the left ventricle (LV). AV, aortic valve; PV, pulmonary valve. (B) This section shows the uppermost portion of the ventricular septal defect (VSD). The mitral valve (MV) is also shown. Comparison with A shows that the VSD is located beneath the aortic valve. (C) Shown are the VSD, the MV, the tricuspid valve (TV), and the right ventricular outflow tract (RV), which is narrowed by hypertrophic muscle (*). (D) The edge of the membranous portion of the ventricular septum (VS), the MV, and the TV are demonstrated. (E) The left and right ventricular walls and cavities are evident, as is the muscular portion of the VS. (F) Transverse section of wild type mouse heart. (G) Sagittal sections of a homozygous mutant heart showing the VSD and the rightward malposition of the AV. (H) View showing the relationships of the AV to the left ventricular outflow tract in the area adjacent to the VS. (I) Sagittal section of wild type mouse heart showing the normal relationships of the VS to the AV and aorta (A).

Copyright

This image is from Tullio AN, Proc Natl Acad Sci U S A 1997 Nov 11;94(23):12407-12. Copyright 1997 National Academy of Sciences, U.S.A. J:44181

Associated Alleles

Symbol	Name
Myh10^tm2Rsad	myosin, heavy polypeptide 10, non-muscle; targeted mutation 1, Robert S Adelstein

Associated Genotypes

Allelic Composition	Genetic Background
Myh10^tm2Rsad/Myh10^tm2Rsad	involves: 129S4/SvJae * C57BL/6J