Phenotype Image Detail

Image

Caption

A: Radiograph of normal bone structure in a 7 month old wild type mouse. B: Radiograph of a 13 month old Col1a2^oim/Col1a2^oim mouse showing generalized osteopenia, marked cortical thinning, bowing of the long bones, scoliosis, sclerosis around the knee joints, and a pronounced dorsal kyphosis. C: Pelvic radiograph of the homozygous mutant mouse in B, showing bowing of the long bones, sclerosis around the knee joints, and fracture callus. Magnification: A; x1.1; B: x0.9; C: x2.0

Copyright

This image is from Chipman SD, Proc Natl Acad Sci U S A 1993 Mar 1;90(5):1701-5. Copyright 1993 National Academy of Sciences, U.S.A. J:4348

Associated Alleles

Symbol	Name
Col1a2^oim	collagen, type I, alpha 2; osteogenesis imperfecta

Associated Genotypes

Allelic Composition	Genetic Background
Col1a2^oim/Col1a2^oim	involves: C3H/HeJ * C57BL/6JLe