Phenotype Image Detail

Image

Caption

A & B: The apical surface of the organ of Corti in Pou4f3^tm1Xia/Pou4f3⁺ mice shows the wild type pattern of stereociliary bundles. (A) Stereociliary bundles emanating from the three rows of outer hair cells are seen to the left of the stereociliary bundles emanation from a single row of inner hair cells. The four rows of hair cells are flanked by supporting cells. (B) A different region of the organ of Corti at high magnification shows stereociliary bundles from two rows of outer hair cells protruding above the microvilli that cover the apical face of supporting cells. C & D: The apical surface of the organ of Corti in Pou4f3^tm1Xia/Pou4f3^tm1Xia mice lacks stereociliary bundles. (D) At high magnification the apical surface is seen to be composed of cells bearing microvilli. Scale bars: A & C: 10um; B & D: 1um

Copyright

This image is from Xiang M, Proc Natl Acad Sci U S A 1997 Aug 19;94(17):9445-50. Copyright 1997 National Academy of Sciences, U.S.A. J:42478

Associated Alleles

Symbol	Name
Pou4f3^tm1Xia	POU domain, class 4, transcription factor 3; targeted mutation 1, M Xiang

Associated Genotypes

Allelic Composition	Genetic Background
Pou4f3^tm1Xia/Pou4f3^tm1Xia	involves: 129S7/SvEvBrd * C57BL/6J