Phenotype Image Detail

Image

Caption

A: Organ of Corti from a Pou4f3^tm1Xia/Pou4f3⁺ mouse stained with cresyl violet shows the wild type arrangement of a single row of inner cells (out of the focal plane) and three rows of outer hair cells (in focal plane). B: Organ of Corti from a wild type mouse stained histochemically for acetylcholine esterase reveals efferent synapses of the three rows of outer hair cells. By contrast, the organ of Corti from a Pou4f3^tm1Xia/Pou4f3^tm1Xia mouse lacks identifiable hair cells (C) and cholinergic innervation (D). Scale bar: 50um

Copyright

This image is from Xiang M, Proc Natl Acad Sci U S A 1997 Aug 19;94(17):9445-50. Copyright 1997 National Academy of Sciences, U.S.A. J:42478

Associated Alleles

Symbol	Name
Pou4f3^tm1Xia	POU domain, class 4, transcription factor 3; targeted mutation 1, M Xiang

Associated Genotypes

Allelic Composition	Genetic Background
Pou4f3^tm1Xia/Pou4f3^tm1Xia	involves: 129S7/SvEvBrd * C57BL/6J