Phenotype Image Detail

Image

Caption

A: Organ of Corti from Pou4f3^tm1Xia/⁺ mouse. The single inner hair cell, the three outer hair cells, and the three underlying Deiter's cells are clearly visible. B: Part of a spiral ganglion from a heterozygous mouse showing a dense packing of myelinated axons and neuronal cell bodies. C: Organ of Corti from a Pou4f3^tm1Xia/Pou4f3^tm1Xia mouse. Inner and outer hair cells are missing and the epithelium beneath the tectorial membrane contains only supporting cells. D: The spiral ganglion from a homozygous mutant mouse contains fewer then one-tenth as many myelinated axons and neuronal cell bodies than the spiral ganglia of the wild type or heterozygous mice. Tissues were embedded in Spurr's resin and 1um sections were stained with methylene blue. Scale bar: 25um

Copyright

This image is from Xiang M, Proc Natl Acad Sci U S A 1997 Aug 19;94(17):9445-50. Copyright 1997 National Academy of Sciences, U.S.A. J:42478

Associated Alleles

Symbol	Name
Pou4f3^tm1Xia	POU domain, class 4, transcription factor 3; targeted mutation 1, M Xiang

Associated Genotypes

Allelic Composition	Genetic Background
Pou4f3^tm1Xia/Pou4f3^tm1Xia	involves: 129S7/SvEvBrd * C57BL/6J