Phenotype Image Detail

Image

Caption

A: An otolith organ from a Pou4f3^tm1Xia/Pou4f3⁺ mouse. Type I hair cells, the most abundant hair cell class, have a lightly stained nerve chalice surrounding a darkly stained cell body. Ciliary bundles can be seen protruding into the densely stained otoliths at the top. A single layer of supporting cells lies beneath the layer of hair cells. B: Crista from a wild type mouse. Type I hair cells are abundant and their ciliary bundles are seen at the left side of the ampullary crest where the section is nearly perpendicular to the apical surface. C & D: Otolith organ (C) and crista (D) from a Pou4f3^tm1Xia/Pou4f3^tm1Xia mouse are devoid of hair cells. Presumptive supporting cells are seen within the epithelium. The density of axon bundles beneath the otolith organ is greatly reduced in the homozygous mouse. Tissues were embedded in Spurr's resin and 1um sections were stained with methylene blue. Scale bar: 25um

Copyright

This image is from Xiang M, Proc Natl Acad Sci U S A 1997 Aug 19;94(17):9445-50. Copyright 1997 National Academy of Sciences, U.S.A. J:42478

Associated Alleles

Symbol	Name
Pou4f3^tm1Xia	POU domain, class 4, transcription factor 3; targeted mutation 1, M Xiang

Associated Genotypes

Allelic Composition	Genetic Background
Pou4f3^tm1Xia/Pou4f3^tm1Xia	involves: 129S7/SvEvBrd * C57BL/6J