Phenotype Image Detail

Image

Caption

A: Collagen fibrils (arrows) are around the smooth muscle cell (star) in the media of the wild type mouse aorta. White areas marked with crosses are elastic fibers. B: Collagen fibrils are missing around the smooth muscle cell (arrows) in the media of the Col3a1^tm1Jae/Col3a1^tm1Jae aorta. C: Cross section of the collagen fibrils in the adventitia of wild type aorta. Arrows point to individual fibrils. The diameter of the collagen fibrils is smaller and relatively uniform compared with the fibrils (arrows) of the mutant mouse aorta in D. E: Skin section of wild type mouse. The collagen fibrils (arrows) are uniform in diameter. F: Skin section of mutant mouse. The collagen fibrils are often thicker (arrows) or thinner (arrowheads) than control fibrils and are not uniform in diameter. Scale bar: A-D: 1um; E & F: 0.2um

Copyright

This image is from Liu X, Proc Natl Acad Sci U S A 1997 Mar 4;94(5):1852-6 SS 18 /C?. Copyright 1997 National Academy of Sciences, U.S.A. J:39273

Associated Alleles

Symbol	Name
Col3a1^tm1Jae	collagen, type III, alpha 1; targeted mutation 1, Rudolf Jaenisch

Associated Genotypes

Allelic Composition	Genetic Background
Col3a1^tm1Jae/Col3a1^tm1Jae	involves: 129S4/SvJae