Phenotype Image Detail

Image

Caption

Smad4^tm1Cxd/Smad4^tm1Cxd embryos (right) and their littermate controls (left). A: E6.5 embryos. Arrow points to the boundary between extraembryonic and embryonic portions of the control embryo. The mutant embryo is round without such a boundary. B: E7.5 embryos. Mutant embryos remain small, however, with a relatively large Reichert's membrane (arrow). C: E8.5 embryos. Arrow points to mutant embryo. Note the increased sizes of mutant embryos compared with those shown at E6.5 and E7.5. D-F: Whole mount hybridization showing the T expression in E7 normal (D), E8.5 mutant(E) and its littermate control (F) embryos. T transcripts were absent in the mutant (E, arrow) but are detected in the control embryos ( D & F, arrows). Lim1 transcripts were also absent in the E8.5 mutant (small arrow in G) but are detected in the control embryos. Abbreviations: ectoplacental cone (epc); head (he); headfold (hf) Scale bar: 270um

Copyright

This image is from Yang X, Proc Natl Acad Sci U S A 1998 Mar 31;95(7):3667-72. Copyright 1998 National Academy of Sciences, U.S.A. J:46852

Associated Alleles

Symbol	Name
Smad4^tm1Cxd	SMAD family member 4; targeted mutation 1, Chu-Xia Deng

Associated Genotypes

Allelic Composition	Genetic Background
Smad4^tm1Cxd/Smad4^tm1Cxd	involves: 129S6/SvEvTac