Phenotype Image Detail

Image

Caption

Parasagittal sections of E18.5 cerebellum with anterior to the left and dorsal to the top. (A and B) Nissl staining. The EGL (arrows) of wild-type cerebellum (A) lies between the meninges and the diffuse Purkinje cell layer (partially marked by arrowheads). The abnormal cerebellum in Cxcr4^tm1Qma/Cxcr4^tm1Qma mice (B) has an irregular EGL (arrows) and large chromophilic cell clumps within the cerebellar anlage. (C and D) Calbindin immunohistochemistry. In comparison with the Purkinje cell layer (arrowheads) in wild-type cerebellum (C), Purkinje cells are located ectopically (arrow) in the homozygous mutant cerebellum (D). (E-I) Chromophilic cell clumps in homozygous mutant cerebellar anlage. Streaming cells from the EGL (E). Combined Nissl and calbindin staining (F). Purkinje cell neurites do not extend into the clumps (asterisks) (G). Adjacent sections stained by Nissl technique (H) or BrdUrd incorporation (I). Scale bar: A-D: 200um; E-H: 50um

Copyright

This image is from Ma Q, Proc Natl Acad Sci U S A 1998 Aug 4;95(16):9448-53. Copyright 1998 National Academy of Sciences, U.S.A. J:49070

Associated Alleles

Symbol	Name
Cxcr4^tm1Qma	C-X-C motif chemokine receptor 4; targeted mutation 1, Qing Ma