Phenotype Image Detail

Image

Caption

Histopathology of Cebpe^tm1Kgx/Cebpe^tm1Kgx mice. In A-E, histological sections of various organs are shown, and in F bone marrow cytospin from 4 month old Cebpe^tm1Kgx/Cebpe^tm1Kgx mice and cytospin preparations of colony-forming unit granulocyte/macrophage colonies from wild-type (G) and homozygous mutant (H) mice are shown. (A) Eyelid (E); intense inflammatory infiltrate consisting of predominantly atypical neutrophils. The infiltrate extends into the palpebral skeletal muscle (S) with associated myofiber degeneration. This conjunctivitis is likely of bacterial etiology. (B) Metatarsus (M); deep cellulitis extending to involve the cortex of the metatarsal bones. The inflammatory cell infiltrate (arrows) is composed predominantly of atypical neutrophils. Myeloid hyperplasia is noted within the marrow cavity (arrowheads). (C) Right caudal lung lobe (L); focally extensive pleuritis and necrotizing pneumonia (Inset). Bacterial rods (arrow) are prominent in the subpleural space. A mixed cell infiltrate consisting of atypical neutrophils and macrophages are present in the pleural exudate (PE) as well as within the affected alveoli (A). (D) Kidney; abscess (A) within renal medulla. Central zone of necrotic cell debris (arrows) admixed with bacterial rods surrounded by a densely cellular infiltrate comprised of atypical neutrophils, macrophages and lymphocytes. A band of fibrous connective tissue separates the abscess from the adjacent renal cortex (RC). (E) Bone marrow; the marrow space is packed with immature myeloid cells (arrow). A number of mitotic figures are present. Some megakaryocytes (arrowhead) are also present. (F) Bone marrow cytospin; immature myeloid cells are noted. Myelocyte (M), metamyelocyte (Meta), and band neutrophil (N) are seen. (G and H) In vitro differentiation. Representative examples of cell morphology by cytospin centrifugation. (G) Cells from wild-type mice; myelocytes (M); neutrophils (N). (H) Cells from homozygous mutant mice; promyelocytes (P); myelocytes (M).

Copyright

This image is from Yamanaka R, Proc Natl Acad Sci U S A 1997 Nov 25;94(24):13187-92. Copyright 1997 National Academy of Sciences, U.S.A. J:76024

Associated Alleles

Symbol	Name
Cebpe^tm1Kgx	CCAAT/enhancer binding protein epsilon; targeted mutation 1, Kleanthis G Xanthopoulos

Associated Genotypes

Allelic Composition	Genetic Background
Cebpe^tm1Kgx/Cebpe^tm1Kgx	involves: 129S6/SvEvTac * NIH Black Swiss
Cebpe^tm1Kgx/Cebpe^tm1Kgx	involves: 129S6/SvEvTac