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Phenotype Image Detail
Image
Caption A-D: Semithin retinal sections of wild type and Rs1tm1Web/Y mice at 2 months of age. In meridional sections, the thickness of the central retina is markedly reduced in hemizygous mice ( B & C) as compared with wild type mice (A). In some hemizygous mouse eyes, photoreceptor outer segments (POS) are present (B), whereas others show partial or complete absence of the POS (C). In hemizygous mouse eyes with areas of preserved POS, large gaps are present between the cells of the INL (arrows in B). Such gaps are absent in areas with complete degeneration of POS(C). D: Oblique tangential section through the INL of an hemizygous mouse retina reveals large extracellular gaps (white arrows). In some of the gaps, cell bodies or microglia are observed (black arrow). Abbreviations: photoreceptor outer segments (os); outer nuclear layer (onl); outer plexiform layer (opl); inner nuclear layer (inl); inner plexiform layer (ipl) ganglion cell layer (gcl). Scale bars: A-C: 25um; D; 2.8um
Copyright This image is from Weber BH, Proc Natl Acad Sci U S A 2002 Apr 30;99(9):6222-7. Copyright 2002 National Academy of Sciences, U.S.A. J:76332
Associated
Alleles
Symbol Name
Rs1tm1Web retinoschisis (X-linked, juvenile) 1 (human); targeted mutation 1, Bernhard H F Weber
Associated
Genotypes
Allelic Composition Genetic Background
Rs1tm1Web/Y involves: 129S1/Sv * C57BL/6
Rs1tm1Web/Y B6.129S1-Rs1tm1Web

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory