Phenotype Image Detail

Image

Caption

A-F: Electron microscopy of the retina of wild type and Rs1^tm1Web/Y mice at 2 months of age. (A) In the retina of wild type mice, typical ribbon synapses are present at the photoreceptor terminals (black arrows). (B) In the retina of hemizygous mice, increased extracellular spaces (open arrow) are observed in regions of ribbon synapses (solid arrow). Larger extracellular gaps are present between individual photoreceptor terminals (asterisk). (C) The extracellular gaps (asterisk) in the INL of hemizygous mice are filled with cellular debris (solid arrows) and membranous whorls (open arrow). (D) Part of the extracellular debris in the INL gaps (asterisk) of hemizygous mice consists of fragmented nerve cell terminals (solid arrow) containing synaptic vesicles. (E) Cells with ultrastructural characteristics of microglia in the retina of hemizygous mice. In the increased extracellular spaces, cells with long cytoplasmic processes (arrows) are observed. (F) Upon higher magnification, multiple clear vesicles (solid arrow) and electron-dense phagolysosomes (open arrow) are observed in the cytoplasm of the cells. Scale bars: A, B, D, & F: 0.53um; C & E: 1.4um

Copyright

This image is from Weber BH, Proc Natl Acad Sci U S A 2002 Apr 30;99(9):6222-7. Copyright 2002 National Academy of Sciences, U.S.A. J:76332

Associated Alleles

Symbol	Name
Rs1^tm1Web	retinoschisis (X-linked, juvenile) 1 (human); targeted mutation 1, Bernhard H F Weber

Associated Genotypes

Allelic Composition	Genetic Background
Rs1^tm1Web/Y	involves: 129S1/Sv * C57BL/6
Rs1^tm1Web/Y	B6.129S1-Rs1^tm1Web