Phenotype Image Detail

Image

Caption

Lateral view of the wild-type (A) and Mapk7^tm1Kda/Mapk7^tm1Kda (B) E9.5 embryos demonstrate retarded cardiac development in homozygous mutant embryos. Arrows point to the heart region. Histological examination of wild type (C) and mutant mouse (D) hearts revealed that mutant mouse hearts failed to undergo normal looping. The common atrial chamber of the mutant hearts also appeared enlarged, the ventricular trabeculations (arrowheads) were attenuated and disorganized, and there was notable pericardial edema (asterisk). High-power magnification of the hearts of wild-type (E) and mutant (F) embryos revealed that the endothelial cells (arrowheads) of mutant hearts were rounded as compared with the thin, elongated cells present in the wild type. Abbreviations: atrium (A); ventricle (V).

Copyright

This image is from Regan CP, Proc Natl Acad Sci U S A 2002 Jul 9;99(14):9248-53. Copyright 2002 National Academy of Sciences, U.S.A. J:77725

Associated Alleles

Symbol	Name
Mapk7^tm1Kda	mitogen-activated protein kinase 7; targeted mutation 1, Keisuke Kuida

Associated Genotypes

Allelic Composition	Genetic Background
Mapk7^tm1Kda/Mapk7^tm1Kda	involves: 129S6/SvEvTac