Phenotype Image Detail

Image

Caption

Whole mount PECAM staining of wild type (A) and Mapk7^tm1Kda/Mapk7^tm1Kda (B) E9.5 embryos revealed defects in vascular maturation/angiogenesis in homozygous mice. Intersomitic vessels (wild type, Lower right insert in A; mutant, Lower right insert in B) appeared normal in homozygous embryos. However, the angiogenic pruning and remodeling that was present in the head region of wild type embryos (Upper right insert in A) was absent in homozygous embryos (Upper right insert in B). Note the disorganized vasculature and lack of complex branching in the mutant embryos. C: Dorsal aorta, wild type. D: Branchial artery, wild type. E: Dorsal aorta, mutant. F: Branchial artery, mutant.

Copyright

This image is from Regan CP, Proc Natl Acad Sci U S A 2002 Jul 9;99(14):9248-53. Copyright 2002 National Academy of Sciences, U.S.A. J:77725

Associated Alleles

Symbol	Name
Mapk7^tm1Kda	mitogen-activated protein kinase 7; targeted mutation 1, Keisuke Kuida

Associated Genotypes

Allelic Composition	Genetic Background
Mapk7^tm1Kda/Mapk7^tm1Kda	involves: 129S6/SvEvTac