Phenotype Image Detail

Image

Caption

B: Histology of a normal adrenal gland from an 18 week old Inha^tm1Bay/Inha^tm1Bay male mouse gonadectomized at 9 weeks. Cells in the cortex (outer layer) are very eosinophilic and arranged in defined zones compared to the medulla (inner layer). Normal mouse adrenal gland is 2mm in diameter. C: Histology of an adrenal tumor (1 x 1.6cm) derived from a 41 week old homozygous mutant male mouse gonadectomized at 6 weeks. Most of the tumor is composed of solid nests of polygonal cells with uniform, central round nuclei and modest amounts of eosinophilic cytoplasm. There are scattered mitoses. Another minority population of small cells of uncertain origin can be seen between the nests of endocrine cells. Elsewhere, many tumors, (including other regions of this tumor) had foci of cystic degeneration, which created a pseudotubular appearance. D: Metastatic adrenal carcinoma in the lung of a 15 month old homozygous mutant female mouse gonadectomized at 5 weeks. These cells are relatively uniform and polygonal with eosinophilic cytoplasm consistent with adrenal cortical origin and are identical to the primary adrenal tumor in this case. There was no primary tumor in the ovaries removed from this mouse. Scalebars: B: 20um; C & D: 10um

Copyright

This image is from Matzuk MM, Proc Natl Acad Sci U S A 1994 Sep 13;91(19):8817-21. Copyright 1994 National Academy of Sciences, U.S.A. J:20450

Associated Alleles

Symbol	Name
Inha^tm1Bay	inhibin alpha; targeted mutation 1, Baylor College of Medicine

Associated Genotypes

Allelic Composition	Genetic Background
Inha^tm1Bay/Inha^tm1Bay	involves: 129S7/SvEvBrd * C57BL/6