Phenotype Image Detail

Image

Caption

At 21 days of age, normal hepatic morphology consists of uniform hepatocytes with bland nuclei that contain small nucleoli (A). In Cbs^tm1Unc/Cbs⁺ mice (B), the hepatocytes have anisonucleosis and fairly prominent nucleoli and appear to be slightly larger. Cbs^tm1Unc/Cbs^tm1Unc mice (C) have enlarged pleomorphic hepatocytes with large, prominent nucleoli. The hepatocytes are frequently binucleated or multinucleated, and their cytoplasm often contains multivesicular cytoplasmic lipid droplets. Magnification: x130

Copyright

This image is from Watanabe M, Proc Natl Acad Sci U S A 1995 Feb 28;92(5):1585-9. Copyright 1995 National Academy of Sciences, U.S.A. J:23321

Associated Alleles

Symbol	Name
Cbs^tm1Unc	cystathionine beta-synthase; targeted mutation 1, University of North Carolina

Associated Genotypes

Allelic Composition	Genetic Background
Cbs^tm1Unc/Cbs^tm1Unc	involves: 129P2/OlaHsd * C57BL/6J
Cbs^tm1Unc/Cbs^+	involves: 129P2/OlaHsd * C57BL/6J