Phenotype Image Detail

Image

Caption

Cardiac abnormalities in Grk2^tm1Mca/Grk2^tm1Mca mouse embryos visualized with hematoxylin and eosin stained sections of whole embryos. Two sections each are shown at the aortic valve and left atrioventricular canal level. A & C are of the wild type embryo. B & D are of the homozygous mutant embryo. Structures are labeled as follows: B, bronchi; DA, descending aorta; EC, endocardial cushion; IVF, interventricular foramen; IVS, interventricular septum; JRDA, junction of the right dorsal aorta; LA, left atrium; LAVC, left atrioventricular canal; LV, left ventricle; RA, right atrium; RV, right ventricle; T, trachea.

Copyright

This image is from Jaber M, Proc Natl Acad Sci U S A 1996 Nov 12;93(23):12974-9. Copyright 1996 National Academy of Sciences, U.S.A. J:36567

Associated Alleles

Symbol	Name
Grk2^tm1Mca	G protein-coupled receptor kinase 2; targeted mutation 1, Marc Caron

Associated Genotypes

Allelic Composition	Genetic Background
Grk2^tm1Mca/Grk2^tm1Mca	involves: 129