Phenotype Image Detail

Image

Caption

Morphology of E18 Cacnb1^tm1Rgg/Cacnb1^tm1Rgg fetuses shows a reduction in muscle mass and disorganization of the myofibrils. A & B: Transverse sections through the hindlimbs of a wild type (A) and homozygous mutant (B) fetus. Sections were cut at approximately the same position and the tibia and fibula can be seen. The amount of muscle in the homozygous mutant fetus is markedly decreased. C: Electron micrograph of a triad from a homozygous mutant fetus. D & E: Electron micrograph of muscle from wild type (D) and homozygous mutant fetus (E). Abbreviations: tibia (T); fibula (F). Scale bars: A & B: 0.3mm; D & E: 1.2um

Copyright

This image is from Gregg RG, Proc Natl Acad Sci U S A 1996 Nov 26;93(24):13961-6. Copyright 1996 National Academy of Sciences, U.S.A. J:37052

Associated Alleles

Symbol	Name
Cacnb1^tm1Rgg	calcium channel, voltage-dependent, beta 1 subunit; targeted mutation 1, Ronald G Gregg

Associated Genotypes

Allelic Composition	Genetic Background
Cacnb1^tm1Rgg/Cacnb1^tm1Rgg	involves: 129S7/SvEvBrd