Phenotype Image Detail

Image

Caption

A: In an Flnb^{Gt(BGB085)Byg}/Flnb^{Gt(BGB085)Byg} mouse at lateral (left) and supine (right) positions, kyphotic and scoliotic malformations of the vertebral column are indicated (arrow) compared with a wild type mouse. Staining is with alcian blue (hyaline cartilage) and alizarin red (bone). B: Reduced hyaline cartilage tissue (blue) is indicated (arrow) in metacarpal bones and phalanges of the wild type mouse. D-G: Intervertebral discs are lacking in the kyphotic and scoliotic areas of the homozygous mutant mouse spine as indicated (G, arrow). F: Hyaline cartilage (blue) around the wild type mouse intervertebral disc as indicated (white arrows) is lacking in the mutant mouse vertebral bone.

Copyright

This image is from Zhou X, Proc Natl Acad Sci U S A 2007 Mar 6;104(10):3919-24. Copyright 2007 National Academy of Sciences, U.S.A. J:120066

Associated Alleles

Symbol	Name
Flnb^Gt(BGB085)Byg	filamin, beta; gene trap BGB085, BayGenomics

Associated Genotypes

Allelic Composition	Genetic Background
Flnb^Gt(BGB085)Byg/Flnb^Gt(BGB085)Byg	involves: 129P2/OlaHsd * C57BL/6