Phenotype Image Detail

Image

Caption

Normal mouse (A,C & E) and Tg(Rho)1Wbae/0 transgenic (B,D & F) littermates. Retinas shown were recovered at 20 days (A & B), 32 days ( C & D) and 7 months (E & F) postpartum. The horizontal arrowheads are located at the level of the retinal pigment epithelium.. The paired asterisks in each paired figure are located at the level of the outer plexiform layer. Photoreceptor outer segments, inner segments and nuclei make up all the cellular mass between the retinal pigment epithelium and outer plexiform layer. The photoreceptor outer segments, located just below the level of the pigment epithelium at 20 days, are shorter in the transgenic mouse than in the normal littermate (A & B). At 32 days, the outer segments remain shorter than their nontransgenic littermates (C & D). Additionally, the number of photoreceptor nuclei in the outer nuclear layer is reduced in the transgenic mouse as compared to the normal littermates. Photoreceptor cells continue to be lost during subsequent months and by 7 months, the transgenic retina contains only two or three rows of photoreceptor nuclei and little outer segment material is apparent (E & F). Scale bar: 25um

Copyright

This image is from Naash MI, Proc Natl Acad Sci U S A 1993 Jun 15;90(12):5499-503. Copyright 1993 National Academy of Sciences, U.S.A. J:12791

Associated Alleles

Symbol	Name
Tg(Rho)1Wbae	transgene insertion 1, Wolfgang Baehr

Associated Genotypes

Allelic Composition	Genetic Background
Tg(Rho)1Wbae/0	involves: C57BL/6 * SJL