Phenotype Image Detail

Image

Caption

Polypodia caudal appendicular skeletal malformations visualized with alizarian red/alcian blue staining. A: Ppd affected founder mouse with normal right pelvis and hindlimb with a severely reduced left hindlimb extending from the normal left pelvis. Anterior to the left limb are two ectopic limbs (partially fused) extending from two ectopic ilial elements. (Skeleton picture in A was compressed for photography, forcing the reduced left hindlimb to the left). B-D: Enlarged elements from Ppd affected founder mouse in A. B: Anterior ectopic legs are fused such that two ectopic tibia share one fibula. C: Normal left limb naturally protruded ventrally on the Ppd affected founder mouse such that the four phalangial autopod directly opposed the baculum (arrow). D: Anterior ectopic limbs have a single polydactylous autopod. E-G: Generation 4 Ppd affected offspring harvested at birth. E: Skeleton is normal above the bold line. A mirror-image ectopic pelvis articulates from the normal ischium/pelvis (below the bold line). Ectopic pelvis gives rise to two additional hindlimbs and an additional pelvic element, which yields an additional mirror-image limb. F: Skeleton with two ectopic hindlimbs (arrows) arising posterior to the normal right limb. G: Skeleton highly similar to the Ppd affected founder mouse except the anterior ectopic legs are more significantly fused. Directions refer to: A: anterior; P: posterior; L: left; R: right; D: dorsal; V: ventral. Skeletal element abbreviations: I: ilium; Is: ischium; P: pubis; F: femur; Fb: fibula; T: tibia; A: autopod. Ectopic skeletal elements are denoted with ('). Asterisk denotes forceps or manually disarticulated at vertebrae to facilitate photography.

Copyright

This image is from Lehoczky JA, Mamm Genome 2006 Sep;17(9):903-13 and is displayed with the permission of Springer Science + Business Media, Inc., New York who owns the copyright. J:112867

Associated Alleles

Symbol	Name
Etn3^Ppd	early transposon element insertion site 3; polypodia

Associated Genotypes

Allelic Composition	Genetic Background
Etn3^Ppd/Y	either: (involves: CD-1) or (involves: C3H/HeJ * CD-1)
Etn3^Ppd/?	either: (involves: CD-1) or (involves: C3H/HeJ * CD-1)