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Caption | Images (A-H) are from 13 day old postnatal mice and are given with their original magnification. A: Dorsal section of an MecomJbo/Evi1+ middle ear cavity (MEC) partly filled with exudate. B: Wild type mouse normal middle ear temporal bone covered with thin mucoperiosteum (arrowheads). C: Wild type mouse inflamed middle ear with thickened mucoperiosteum with neutrophil leukocyte infiltrates and neutrophil rich exudates in the MEC. D: Mutant mouse middle ear with more severe suppurative exudation into the MEC. E: Mutant mouse inflamed edematous polyp (arrowhead) of un-resorbed embryonic middle ear connective tissue, tympanic membrane. F: Mutant mouse MEC lined by ciliated columnar cells (arrowhead). G: Mutant mouse MEC lined by basal cells (arrowhead). H: Mutant mouse suppurative rhinitis: nasal cavity with suppurative exudate, nasal septum with inflamed nasal mucosa. Images I-L are of adult (180 day old) mutant mouse middle ear with chronic suppurative Otitis Media (OM); changes include (I) fibrous polyps (arrowheads) (J) hyperplasia of ciliated epithelial cells (arrowhead) and fibrosis of mucoperiosteum stroma, and (K) fibrous thickening of the tympanic membrane, outer ear canal compared with (L) normal wild type tympanic membrane, outer ear canal. Abbreviations: E: exudate; MP: mucoperiosteum; NC: nasal cavity; NM: nasal mucosa; NS: nasal septum; OEC: outer ear canal; TB: temporal bone; TM: tympanic membrane. Magnifications: A: x40; B,C,D,J,K & L: x400; E: x100; F & G: x600; H & I: x200 | ||||
Copyright | This image is from Parkinson N, PLoS Genet 2006;2(10):e149, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:113445 | ||||
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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