Phenotype Image Detail

Image

Caption

Images (A-H) are from 13 day old postnatal mice and are given with their original magnification. A: Dorsal section of an Mecom^Jbo/Evi1⁺ middle ear cavity (MEC) partly filled with exudate. B: Wild type mouse normal middle ear temporal bone covered with thin mucoperiosteum (arrowheads). C: Wild type mouse inflamed middle ear with thickened mucoperiosteum with neutrophil leukocyte infiltrates and neutrophil rich exudates in the MEC. D: Mutant mouse middle ear with more severe suppurative exudation into the MEC. E: Mutant mouse inflamed edematous polyp (arrowhead) of un-resorbed embryonic middle ear connective tissue, tympanic membrane. F: Mutant mouse MEC lined by ciliated columnar cells (arrowhead). G: Mutant mouse MEC lined by basal cells (arrowhead). H: Mutant mouse suppurative rhinitis: nasal cavity with suppurative exudate, nasal septum with inflamed nasal mucosa. Images I-L are of adult (180 day old) mutant mouse middle ear with chronic suppurative Otitis Media (OM); changes include (I) fibrous polyps (arrowheads) (J) hyperplasia of ciliated epithelial cells (arrowhead) and fibrosis of mucoperiosteum stroma, and (K) fibrous thickening of the tympanic membrane, outer ear canal compared with (L) normal wild type tympanic membrane, outer ear canal. Abbreviations: E: exudate; MP: mucoperiosteum; NC: nasal cavity; NM: nasal mucosa; NS: nasal septum; OEC: outer ear canal; TB: temporal bone; TM: tympanic membrane. Magnifications: A: x40; B,C,D,J,K & L: x400; E: x100; F & G: x600; H & I: x200

Copyright

This image is from Parkinson N, PLoS Genet 2006;2(10):e149, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:113445

Associated Alleles

Symbol	Name
Mecom^Jbo	MDS1 and EVI1 complex locus; Junbo

Associated Genotypes

Allelic Composition	Genetic Background
Mecom^Jbo/Mecom^+	C3N.C-Mecom^Jbo