Phenotype Image Detail

Image

Caption

A-E: Radiographs of front paws (A & B) and hindpaws (C-E) of 7 month old wild type (A & C), Fgr^Mhdaali18/Ali18⁺ (D) and Fgr^Mhdaali18/Fgr^Mhdaali18 mice. Phalanges of the homozygote are affected. Open boxes indicate destruction of bones and joints. F-I: Reconstructed images from microcomputed tomography scans. Khaki-colored regions indicate calcified bone tissue in black background, and pink areas mark sectioned surfaces. Sagittal sections of lumbar vertebrae are shown in (F) wild type and (G) homozygous mutant mice. Blue lines in (G) indicate reduced bone density in vertebral bodies and arches in the homozygous mutant mouse. Sagittal sections of the knee joint region shown in (H) wild type and (I) homozygous mutant mice. Increased bone marrow regions of mutant femur are indicated by asterisks.

Copyright

This image is from Abe K, Mamm Genome 2006 Sep;17(9):915-26 and is displayed with the permission of Springer Science + Business Media, Inc., New York who owns the copyright. J:112868

Associated Alleles

Symbol	Name
Fgr^Mhdaali18	FGR proto-oncogene, Src family tyrosine kinase; Abnormal limb

Associated Genotypes

Allelic Composition	Genetic Background
Fgr^Mhdaali18/Fgr^Mhdaali18	C3HeB/FeJ-Fgr^Mhdaali18