Phenotype Image Detail

Image

Caption

Socs7^tm1Wsa/Socs7^tm1Wsa mice were analyzed clinically and pathohistologically for anatomical abnormalities. Images of wild type or Socs7^tm1Wsa/⁺ controls are shown in A, C, E, G, K (Left) and L (Left) and images of homozygous mutants are shown in B, D, F, H-J, K (Right) and L (Right). A & B: Homozygous mice exhibit reduced activity, failure to feed and macrocephalus. C-F: Expansion of the fluid filled lateral ventricles evident in hematoxylin/eosin stained section of brains within skulls. Note the disruption of the septum (arrow in D) and the retrosplenial cortex to hippocampus transition (arrow in F). G-J: Disorganization of the subcommissural organ (SCO) in homozygous mutant (H-J) compared with the defined structure of the wild type control mice (G). K & L: Homozygous mutant mice (right) with overt hydrocephalus exhibited a failure of calvarial bone suture closure (arrows), whereas sutures were closed in age-matched controls (left). Abbreviations: 3V: third ventricle; Cx: cerebral cortex; Ep: ependyma; Fr: frontal bone; Hi: hippocampus; Ht: hypothalamus; Hy: hypependyma; LV: lateral ventricle; MN: mammillary nuclei; Oc: occipital bone; PC: posterior commissure; Th: thalamus; Se: septum; St: striatum; Pa: paraietal bone Scalebars: C & D: 2mm; G-J: 40um; K: 7.1mm; L: 4.4mm

Copyright

This image is from Krebs DL, Proc Natl Acad Sci U S A 2004 Nov 26;101(43):15446-51. Copyright 2004 National Academy of Sciences, U.S.A. J:93449

Associated Alleles

Symbol	Name
Socs7^tm1Wsa	suppressor of cytokine signaling 7; targeted mutation 1, Warren S Alexander

Associated Genotypes

Allelic Composition	Genetic Background
Socs7^tm1Wsa/Socs7^tm1Wsa	involves: C57BL/6