Phenotype Image Detail

Image

Caption

A: Exencephaly (denoted by arrowheads) in E13.5 Frem2^my-F11/Frem2^my-F11 mutant. B & C: Earliest visible hemorrhages in the choroid plexuses. Hemorrhage in the rostral (B) and caudal (C) choroid plexus of two representative E13.5 embryos. (Inserts) Locations of the defect). D: Blood-filled blisters on the surface of an E13.5 embryo, with an internal hemorrhage (arrowhead) in the caudal choroid plexus. E: Hemorrhage on the E15.5 palate. (Insert) Lower magnification view of the head. F: Two hemorrhages on the head of an E15.5 embryo; the outer hemorrhage (arrowhead) appears to be nearly resolved, whereas the inner, subdermal one (arrow) appears to be recently formed. G: Hemorrhage on the head of a newborn mutant mouse. H: Adult mutant mouse head, showing reduced or absent eyes (arrows), reduced ear (arrowhead), and discoloration of fur (white asterisk).

Copyright

This image is from Timmer JR, Proc Natl Acad Sci U S A 2005 Aug 16;102(33):11746-50. Copyright 2005 National Academy of Sciences, U.S.A. J:101189

Associated Alleles

Symbol	Name
Frem2^my-F11	Fras1 related extracellular matrix protein 2; my-F11

Associated Genotypes

Allelic Composition	Genetic Background
Frem2^my-F11/Frem2^my-F11	either: (involves: C3HeB/FeJ * C57BL/6J) or (involves: C3HeB/FeJ * C57BL/6J * M. m. castaneus)