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Caption | A-E: Limb defects of a Frem2my-F11/Frem2my-F11 mice. Shown are a fluid-filled blister on an E14.5 hind limb(A); a blood-filled blister encompassing distal structures of an E14.5 hind limb (B); a hemorrhage associated with malformation and dorsal flexure of the newborn hind limb (C); a malformed adult limb, showing reversal of flexure and soft tissue syndactyly (D); and a severely malformed adult limb (E). G: Section of an E15.5 mutant mouse heart, showing failure of atria septation (arrow) and a defect in ventricular valves (arrowhaed). Note that both ventricles drain into a single large chamber. H: Newborn mutant mouse lungs, showing failure of proper lung septation. The arrows point to lobe fusion. I: Section of newborn mutant mouse lung, showing normal morphology. The arrows denote regions where the lung lobes have fused, and the arrowhead denotes a region with a limited adhesion between the two lobes. | ||||
Copyright | This image is from Timmer JR, Proc Natl Acad Sci U S A 2005 Aug 16;102(33):11746-50. Copyright 2005 National Academy of Sciences, U.S.A. J:101189 | ||||
Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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