Phenotype Image Detail

Image

Caption

A-F and I-K: Von Kossa-stained coronal sections through proximal tibias of individual 12 week old mice. Note the general increase in number of bone trabeculae (arrows) in LiCl mice. hPTH-treated SAMP6 mouse serves as a positive control. A-C: Homozygous mutant mice that were gavage fed vehicle. D-F: Homozygous mutant mice that were gavage fed LiCl. G & H: Three-dimensional microCT reconstruction of proximal tibias from mutant mice treated with vehicle (G) and treated with LiC1 (H), showing increased trabecular bone volume in response to lithium. I: SAMP6 mouse gavage fed vehicle. J: SAMP6 mouse gavage fed LiCl. K: SAMP6 mouse treated with hPTH. L-P: H&E-stained trabecular bone from the proximal tibias of individual 12-week-old mice looking at marrow adiposity. L: Mutant mouse that was gavage fed vehicle. M: Mutant mouse that was gavage fed LiC1. N: SAMP6 mouse that was gavage fed vehicle. O: SAMP6 mouse that was gavage fed LiCl. P: SAMP6 mouse that received s.c. hPTH.

Copyright

This image is from Clement-Lacroix P, Proc Natl Acad Sci U S A 2005 Nov 29;102(48):17406-11. Copyright 2005 National Academy of Sciences, U.S.A. J:104382

Associated Alleles

Symbol	Name
Lrp5^tm1Grw	low density lipoprotein receptor-related protein 5; targeted mutation 1, Georges Rawadi

Associated Genotypes

Allelic Composition	Genetic Background
Lrp5^tm1Grw/Lrp5^tm1Grw	involves: 129S1/Sv * 129X1/SvJ