Phenotype Image Detail

Image

Caption

Views are shown of the thoracic (A-D) and cervical (E & F) regions of skeletons of wild type (A & E) and Kmt2a^tm1Djab/Kmt2a^tm1Djab mice (B-D & F). Typical sternal abnormalities were dectected in the homozygous mutant mice. The additional ossification center is indicated by an arrow in B. Two different fusions between ribs are shown ( C & D, indicated by arrows). Lateral views of the cervical region of a wild type (E) and mutant mouse (F) are shown. Homozygous mutant mice present bone abnormalities in the cervical region. The C2 vertebra is broadened (C2*). The anterior arch of the atlas is severely reduced (aaa*). C6 (black arrow) show posterior transformation to C7.

Copyright

This image is from Terranova R, Proc Natl Acad Sci U S A 2006 Apr 25;103(17):6629-34. Copyright 2006 National Academy of Sciences, U.S.A. J:109102

Associated Alleles

Symbol	Name
Kmt2a^tm1Djab	lysine (K)-specific methyltransferase 2A; targeted mutation 1, Malek Djabali

Associated Genotypes

Allelic Composition	Genetic Background
Kmt2a^tm1Djab/Kmt2a^tm1Djab	involves: 129P2/OlaHsd * BALB/c