Phenotype Image Detail

Image

Caption

Light (A,B,E,F,I & J; x200) and electron (C,D,G,H,K. and L x5000) microscopy of kidneys from wild type and age matched Ro60^tm1Woln/Ro60^tm1Woln. Homozygous mutant and wild type mice from the original hybrid strain (A-D) were examined at 16.5 months, and backcrossed mice were examined at 7 (E-H) and 12.5 (I-L) months. Age matched wild type mice show essentially normal histology. The hybrid homozygous mutant mice show glomerular hypercellularity with large eosinophilic capillary deposits (B, arrow), which correspond to subendothelial immune complexes (D, arrow). Lesions in the backcrossed mice are less severe, with mesangial immune complexes at 7 months (H, arrow) and larger subendothelial complexes at 12.5 months (L, arrow).

Copyright

This image is from Xue D, Proc Natl Acad Sci U S A 2003 Jun 24;100(13):7503-8. Copyright 2003 National Academy of Sciences, U.S.A. J:84627

Associated Alleles

Symbol	Name
Ro60^tm1Woln	Ro60, Y RNA binding protein; targeted mutation 1, Sandra L Wolin

Associated Genotypes

Allelic Composition	Genetic Background
Ro60^tm1Woln/Ro60^tm1Woln	involves: 129S1/Sv * C57BL/6