Phenotype Image Detail

Image

Caption

Wild type embryos (left); Jag1^Mhdahtu/Jag1^Mhdahtu embryos (right). A & B: Yolk sacs (still containing embryos) obtained at E11.5 show the absence of large blood vessels in the homozygous embryos. C & D: E11.5 embryos demonstrating the hemorrhaging observed in the mutant embryos. E & F: E10.5 embryos process for anti-PECAM immunohistochemistry to detect vascular defects in the embryos. Arrows indicate one of the large blood vessels in the head, which is thicker in the mutant and appears to undergo less branching in the mutant. Scale bar: 1mm in D (for A-D) and 500um in F (for E & F)

Copyright

This image is from Kiernan AE, Proc Natl Acad Sci U S A 2001 Mar 27;98(7):3873-8. Copyright 2001 National Academy of Sciences, U.S.A. J:72108

Associated Alleles

Symbol	Name
Jag1^Mhdahtu	jagged 1; Martin Hrabe de Angelis headturner

Associated Genotypes

Allelic Composition	Genetic Background
Jag1^Mhdahtu/Jag1^Mhdahtu	C3HeB/FeJ-Jag1^Mhdahtu